hEpCAM/MC-38
CBPG0151
询 价
留 言
产品描述
产品数据库
| I. Background | |
| EpCAM（Epithelial Cell Adhesion Molecule，上皮细胞粘附分子，CD326）是一种跨膜 糖蛋白，在细胞的信号传导、粘附、细胞增殖分化、器官形成和维持中起着重要作用。 EpCAM 基因在人胚胎期除了胸腺组织以外的几乎所有的上皮组织中表达。在正常成人组 织中，EpCAM 在胃肠道、生殖系统和呼吸道的各种组织中的简单、假复层和移行上皮细 胞的基底外侧面表达。EpCAM 发生功能缺失性突变会导致先天性簇绒性肠病，在病理条 件下，EpCAM 在起源于上皮细胞的癌症中特异性表达。此外，EpCAM 在肺癌、乳腺癌、 宫颈癌和胰腺癌等多种癌症中高表达。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hEpCAM |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+5 μg/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
|
|
|
| V. In VIVO Data | |
|
Index |
Content |
|
Animal |
C57BL/6J, 6weeks, female |
|
Implanted Position |
Subcutaneous (right lower flank region) |
|
Injected Cell Numbers |
1×10^6/0.1ml |
|
Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hEpCAM/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hEpCAM/MC38 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
